Methylphenidate may diminish antihypertensive effects. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor. Risk of acute hypertensive episode. Monitor BP. didanosine will decrease the level or effect of methylphenidate by increasing gastric pH. Interaction more likely in certain predisposed pts. Interaction more likely in certain predisposed pts. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor Closely (1)formoterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Use Caution/Monitor. 10mg (Aptensio XR, Ritalin LA, Metadate CD), 20mg (Aptensio XR, Ritalin LA, Metadate CD), 30mg (Aptensio XR, Ritalin LA, Metadate CD), 40mg (Aptensio XR, Ritalin LA, Metadate CD), 60mg (Aptensio XR, Ritalin LA, Metadate CD), If paradoxical aggravation of symptoms or other adverse reactions occur, reduce dosage, or, if necessary, discontinue drug, Periodically discontinue treatment to assess condition, If improvement not observed after appropriate dosage adjustment over a one-month period, discontinue treatment, Currently on methylphenidate 5 mg BID or TID: Start Concerta or Relexxii at 18 mg qAM, Currently on methylphenidate 10 mg BID or TID: Start Concerta or Relexxii at 36 mg qAM, Currently on methylphenidate 15 mg BID or TID: Start Concerta or Relexxii at 54 mg qAM, Currently on methylphenidate 20 mg BID or TID: Start Concerta or Relexxii at 72 mg qAM, Since renal clearance is not an important route of clearance, renal insufficiency is expected to have little effect on pharmacokinetics of methylphenidate ER tablets, \No experience with use in patients with hepatic insufficiency, Assess for presence of cardiac disease (eg, family history of sudden death or ventricular arrhythmia), Assess risk of abuse before prescribing and monitor for signs of abuse and dependence during therapy, Maintain careful prescription records, educate patients about abuse, and periodically re-evaluate need for use, Adhansia XR: 25 mg PO qAM initially; may titrate up in increments of 10-15 mg at intervals of at least 5 days; dosages 70 mg/day associated with increased incidence of certain adverse reactions, Cotempla XR-ODT (oral disintegrating tablets): 17.3 mg PO qAM initially; may titrate upward weekly by 8.6-17.3 mg increments; not to exceed 51.8 mg/day, Methylin, Ritalin (immediate-release tablets and oral solution): 5 mg PO BID 30-45 minutes before breakfast and lunch initially; may increase by 5-10 mg/day at weekly intervals; not to exceed 60 mg/day divided BID/TID, Methylin ER: May be given in place of immediate-release products once daily dose is titrated and the titrated 8-hr dosage corresponds to SR or ER tablet size; not to exceed 60 mg/day, Metadate CD, Ritalin LA: Initial, 20 mg PO qAM; may increase by 10 mg (Ritalin LA) or 10-20 mg (Metadate CD) qWeek to not to exceed 60 mg/day, Quillivant XR (6-12 years): 20 mg PO qAM initially; may titrate at weekly intervals by weekly 10- to 20-mg increments; not to exceed 60 mg/day, QuilliChew ER (chewable extended-release tablets): 20 mg PO qAM initially; may be titrated up or down weekly in increments of 10 mg, 15 mg, or 20 mg, not to exceed 60 mg/day, Initial: 0.3 mg/kg/dose PO before breakfast and lunch; may increase by 0.1 mg/kg/dose qWeek, Maintenance: 0.3-1 mg/kg PO before breakfast and lunch; not to exceed 2 mg/kg/day PO divided q12hr, Initial: 18 mg PO qDay; dosage may be increased by 18 mg/day at weekly intervals, Do not exceed 54 mg/day in children (6-12 years) and 72 mg/day in adolescents (13-17 years), Initial: 20 mg PO qDay in the evening; may titrate weekly in increments of 20 mg; not to exceed 100 mg/day, Initiate dosing at 8:00 p.m.; adjust timing of administration between 6:30 pm and 9:30 pm to optimize tolerability and efficacy the next morning and throughout the day, Methylin, Ritalin (immediate-release tablets and oral solution): 5 mg PO q12hr; may increase by 5-10 mg/day weekly; not to exceed 60 mg/day, Methylin ER,: May be given in place of immediate-release products once the daily dose is titrated and the titrated 8-hour dosage corresponds to ER tablet size; not to exceed 60 mg/day, No experience with use in patients with hepatic insufficiency, Assess risk of abuse before prescribing and monitor for signs of abuse and dependence while on therapy, Maintain careful prescription records, educate patients about abuse, and periodically re-evaluate the need for use, Patients <6 years of age experienced higher plasma exposure than patients aged 6 at the same dose and high rates of adverse reactions, most notably weight loss, CNS stimulants, including methylphenidate-containing products, and amphetamines, have a high potential for abuse and dependence, Assess the risk of abuse before prescribing, and monitor for signs of abuse and dependence during therapy, Motor tics or family history or diagnosis of Tourette syndrome, Patients with marked anxiety, tension, and agitation, Contains sucrose; do not administer to patients with hereditary problems of fructose intolerance, glucose-galactose malabsorption, or sucrase-isomaltase insufficiency, Tablet formulation is nondeformable and does not appreciably change in shape in the GI tract, Do not administer to patients with pre-existing severe gastrointestinal narrowing conditions, including esophageal motility disorders,small bowel inflammatory disease, "short gut" syndrome due to adhesions or decreased transit time, cystic fibrosis, history of peritonitis, or chronic intestinal pseudo-obstruction, or Meckel diverticulum, Use only in patients who can swallow tablets whole, CNS stimulants may exacerbate symptoms of behavior disturbance and thought disorder in patients with a preexisting psychotic disorder, CNS stimulants may also induce a manic or mixed episode in patients, Before initiating treatment, screen for risk factors for developing a manic episode (eg, history or family history of suicide, bipolar disorder, and depression), CNS stimulants at recommended doses, may cause psychotic or manic symptoms (eg, hallucinations, delusional thinking, or mania) in patients without a prior history of psychotic illness or mania; consider discontinuing therapy if such symptom occur, Sudden death, stroke, and myocardial infarction report in adults, Sudden death reported in pediatric patients with structural cardiac abnormalities and other serious heart problems, Avoid use in patients with known structural cardiac abnormalities, cardiomyopathy, serious heart rhythm abnormalities, coronary artery disease, and other serious heart problems, Further evaluate for developing exertional chest pain, unexplained syncope, or arrhythmias during treatment, 45-mg capsules contain FD&C yellow #5 (tartrazine) which may cause allergic-type reactions (including bronchial asthma) in certain susceptible persons, Do administer during or within 14 days of discontinuing MAOI treatment, Coadministration of MAOIs with CNS stimulants can cause hypertensive crisis, which increases the risk of death, stroke, myocardial infarction, aortic dissection, ophthalmological complications, eclampsia, pulmonary edema, and renal failure, Monitor BP and adjust dose of antihypertensive drugs accordingly, Methylphenidate may decrease effectiveness of antihypertensive drugs, Avoid using methylphenidate on day of surgery, Methylphenidate concomitantly used halogenated anesthetics may potentiate the risk of sudden BP and HR increase during surgery, Monitor for signs of extrapyramidal symptoms (EPS), Dose changes in either risperidone and/or methylphenidate may increase the risk of EPS, Monitor and use alternant based on clinical response, Gastric pH modulators (eg, proton pump inhibitors, H2-blockers) may change the release, pharmacokinetic profiles, and pharmacodynamics of Adhansia XR, No teratogenic effects were observed with oral administration of methylphenidate to pregnant rats and rabbits during organogenesis at doses up to 2x and 9x the maximum recommended human dose (MRHD) of 100 mg/day given to adolescents on a mg/m2 basis, respectively, However, spina bifida was observed in rabbits at a dose 31x the MRHD given to adolescents, Decrease in pup body weight was observed in a pre- and postnatal development study with oral administration of methylphenidate to rats throughout pregnancy and lactation at doses 3.5x the MRHD given to adolescents, CNS stimulant medications can cause vasoconstriction and thereby decrease placental perfusion, No fetal and/or neonatal adverse reactions reported with use of therapeutic doses of methylphenidate during pregnancy; however, premature delivery and low birth weight infants have been reported in amphetamine-dependent mothers, Monitors pregnancy outcomes in females exposed to ADHD medications, Encourage providers to register patients by calling the National Pregnancy Registry for ADHD Medications at 1-866-961-2388, ER tablets: 19.3-19.7 ng/mL(72-mg dose); 3.7 ng/mL (18 mg-dose), Aptensio XR: 23.47 ng/mL (capsule); 21.78 ng/mL (sprinkle), ER tablets: 5.5 hr (72-mg dose); 6.8 hr (18-mg dose), Adhansia XR: 1.5 hr (1st median range time); 12 hr (2nd median range time), ER tablets: 200.9-206.1 nghr/mL (72-mg dose); 41.8 nghr/mL (18-mg dose), Aptensio XR: 258.1-262.7 nghr/mL (capsule): 258-262.9 nghr/mL (sprinkle), Aptensio XR: 5.09 hr (capsule); 5.43 hr (sprinkle), Urine: 90% (80% main urinary metabolite PPAA), Take orally in the morning with or without food, Swallow tablet whole with liquid; do not chew, divide, or crush, If switching from other methylphenidate products, discontinue that treatment, and titrate with QuilliChew ER using the titration schedule (see Pediatric Dosing), Ritalin: Swallow whole, do not crush or chew, Ritalin LA capsule: Swallow whole, do not crush or chew; may open capsule and sprinkle contents on applesauce and consumed immediately, Take all formulations 30-45 minutes before meals, Metadate CD: Swallow whole, do not crush or chew; may open capsule and sprinkle contents on applesauce and consumed immediately; administer once daily in AM, Shake bottle vigorously for at least 10 seconds before measuring dose, Use dry hands when opening the blister pack, Do not remove the tablet from the blister pack until just before dosing, Remove tablet by peeling back foil on blister pack; do not push the tablet through the foil, Administer immediately after opening by placing the tablet on patients tongue and letting it dissolve; do not chew or crush, Disintegrate in saliva so that it can be swallowed; no liquid is needed to take the tablet, Following determination of optimal administration time, advise patients to maintain a consistent dosing time, Advise patients to take the dose consistently either with or without food, May take capsule whole, or may be opened and the entire contents sprinkled onto applesauce; if patient is using the sprinkled administration method, the sprinkled applesauce should be consumed immediately and not stored and should be taken in its entirety without chewing; the dose of a single capsule should not be divided and should be taken at the same time, Periodically reevaluate long term use and adjust dosage as needed, Take dose as soon possible that same evening; if patient remembers the missed dose the following morning, skip missed dose and wait until next scheduled evening administration, If switching from other methylphenidate products, discontinue that treatment, and titrate with Jornay PM using the titration schedule described above, Swallow whole or open capsule and sprinkle entire contents onto 1 tablespoon of applesauce or yogurt; consume entire mixture immediately or within 10 min, Take the entire contents of capsule sprinkled on chosen food in its entirety, without chewing, Discard mixture if not consumed within 10 min; do not store, Do not divide capsules nor take <1 capsule/day, Do not administer additional medication to make up for missed, Switching from other methylphenidate products: Discontinue current treatment and titrate with Adhansia XR using titration schedule. Monitor BP. Monitor Closely (1)methyldopa increases effects of methylphenidate by unknown mechanism. Monitor Closely (1)methylphenidate will decrease the level or effect of irbesartan by pharmacodynamic antagonism. Use Caution/Monitor. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor Closely (1)methylphenidate will decrease the level or effect of moexipril by pharmacodynamic antagonism. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Individual plans may vary methylphenidate will decrease the level or effect of isradipine by pharmacodynamic antagonism. Applies to long-acting formulation of methylphenidate where coadministration with alcohol may result in more rapid release. Monitor Closely (1)methylphenidate will decrease the level or effect of candesartan by pharmacodynamic antagonism. Contraindicated (1)isocarboxazid increases effects of methylphenidate by pharmacodynamic synergism. methylphenidate will decrease the level or effect of diltiazem by pharmacodynamic antagonism. Monitor BP. Avoid or Use Alternate Drug. Monitor BP. Use Caution/Monitor. Use Caution/Monitor. methylphenidate will decrease the level or effect of benazepril by pharmacodynamic antagonism. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Monitor Closely (1)methylphenidate will decrease the level or effect of ramipril by pharmacodynamic antagonism. Contraindicated. Use Caution/Monitor. Risk of acute hypertensive episode. Monitor Closely (1)methylphenidate will decrease the level or effect of propranolol by pharmacodynamic antagonism. Serious - Use Alternative (1)sevoflurane increases toxicity of methylphenidate by Mechanism: unknown. Interaction more likely in certain predisposed pts. Minor/Significance Unknown. Risk of acute hypertensive episode. Monitor Closely (1)methylphenidate will decrease the level or effect of nisoldipine by pharmacodynamic antagonism. Methylphenidate may diminish antihypertensive effects. Methylphenidate may diminish antihypertensive effects. Concerta is a long-acting drug: It increases dopamine steadily. Use Caution/Monitor. Minor/Significance Unknown. Other (see comment). Serious - Use Alternative (1)dihydroergotamine, methylphenidate. Use Caution/Monitor. Use Caution/Monitor. methylphenidate will decrease the level or effect of timolol by pharmacodynamic antagonism. Use Caution/Monitor. Mechanism: unknown. Use Caution/Monitor. Serious - Use Alternative (1)lofepramine, methylphenidate. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. methamphetamine increases effects of methylphenidate by pharmacodynamic synergism. Contraindicated. Your doctor may adjust your dose as needed. Use Caution/Monitor. Minor (1)amantadine, methylphenidate. Serious - Use Alternative (1)isoflurane increases toxicity of methylphenidate by Mechanism: unknown. In general, administer drugs at least 2 hr before or after sodium zirconium cyclosilicate. Conversion from methylphenidate to Concerta or Relexxii. Applies only to oral form of both agents. Methylphenidate may diminish antihypertensive effects. Risk of acute hypertensive episode. By clicking send, you acknowledge that you have permission to email the recipient with this information. Mechanism: unknown. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. lansoprazole decreases effects of methylphenidate by enhancing GI absorption. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. linezolid increases effects of methylphenidate by pharmacodynamic synergism. Monitor BP. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Concerta and Ritalin share the same active ingredient. Monitor BP. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Risk of acute hypertensive episode. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Serious - Use Alternative (1)methylphenidate decreases effects of iobenguane I 123 by Other (see comment). Monitor BP. Comment: Green tea may include caffeine. Additive pressor effect. Monitor Closely (1)sufentanil SL, methylphenidate. and formulary information changes. Monitor Closely (1)albuterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. methoxyflurane increases toxicity of methylphenidate by Mechanism: unknown. ether increases toxicity of methylphenidate by Mechanism: unknown. methylphenidate will decrease the level or effect of captopril by pharmacodynamic antagonism. Interaction more likely in certain predisposed pts. Contraindicated. Modify Therapy/Monitor Closely. Potential for additive CNS stimulation. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Risk of acute hypertensive episode. Applies only to oral form of both agents. Monitor BP. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor for hypertension with concomitant use. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Avoid or Use Alternate Drug. Potential for additive CNS stimulation. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Monitor BP. dopexamine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Risk of acute hypertensive episode. hydrocodone, methylphenidate. Use Caution/Monitor. Vyvanse) in the right column ADHDMedCalc.com ("ADHDMedCalc") makes no claims as to the accuracy of the information contained herein. Methylphenidate may diminish antihypertensive effects. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. You are being redirected to provider for the most current information. Use Caution/Monitor. Share cases and questions with Physicians on Medscape consult. fluphenazine increases toxicity of methylphenidate by pharmacodynamic antagonism. Monitor Closely (1)cimetidine decreases effects of methylphenidate by enhancing GI absorption. Use Caution/Monitor. Risk of acute hypertensive episode. pirbuterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Mechanism: unknown. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. The generic drug name of Concerta is methylphenidate. Additive vasospasm; risk of hypertension. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)pirbuterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Contraindicated. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Methylphenidate may diminish antihypertensive effects. Contraindicated. Use Caution/Monitor. Monitor for increased serum concentrations/toxicity of phenytoin if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is discontinued/dose decreased. Monitor BP. Avoid or Use Alternate Drug. Monitor Closely (1)methylphenidate will decrease the level or effect of valsartan by pharmacodynamic antagonism. Monitor BP. Closely monitor blood pressure with concomitant use of esketamine nasal with stimulants. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Monitor BP. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. If you log out, you will be required to enter your username and password the next time you visit. Monitor Closely (1)epinephrine racemic and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Mechanism: pharmacodynamic synergism. Monitor Closely (2)trifluoperazine, methylphenidate. Applies only to extended release formulation. fluphenazine, methylphenidate. Monitor BP. ozanimod increases toxicity of methylphenidate by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Risk of acute hypertensive episode. Risk of acute hypertensive episode. Use Caution/Monitor. Use Caution/Monitor. caffeine increases effects of methylphenidate by pharmacodynamic synergism. Mechanism: pharmacodynamic synergism. Caffeine should be avoided or used cautiously. Interaction more likely in certain predisposed pts. Monitor Closely (1)doxepin, methylphenidate. methylphenidate and solriamfetol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor Closely (1)methylphenidate will decrease the level or effect of azilsartan by pharmacodynamic antagonism. Mechanism: unknown. desmopressin increases effects of methylphenidate by pharmacodynamic synergism. Risk of acute hypertensive episode. Monitor BP. Use Caution/Monitor. Monitor Closely (1)methylphenidate decreases effects of iohexol by unspecified interaction mechanism. Other (see comment). Risk of V tach, HTN. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Risk of acute hypertensive episode. Methylphenidate may diminish antihypertensive effects. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. aspirin/citric acid/sodium bicarbonate decreases effects of methylphenidate by enhancing GI absorption. Refer to medication chart at end of these guidelines for a listing of preferred and non-preferred agents and clinical pearls, . Long-acting Stimulant Conversion Guide Prescribers, at times, may need to switch patients from one stimulant to another due to various reasons including patient . Methylphenidate may diminish antihypertensive effects. Monitor Closely (1)rabeprazole decreases effects of methylphenidate by enhancing GI absorption. Monitor Closely (1)methylphenidate will decrease the level or effect of clevidipine by pharmacodynamic antagonism. Compare formulary status to other drugs in the same class. Either increases effects of the other by pharmacodynamic synergism. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Monitor BP. Use Caution/Monitor. amantadine, methylphenidate. Additive vasospasm; risk of hypertension. Concerta is long-acting Ritalin (methylphenidate). Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Interaction more likely in certain predisposed pts. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Amifampridine. Monitor for hypertension with concomitant use. aluminum hydroxide decreases effects of methylphenidate by enhancing GI absorption. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Applies only to oral form of both agents. Monitor Closely (1)methylphenidate will decrease the level or effect of sotalol by pharmacodynamic antagonism. Use Caution/Monitor. Applies only to oral form of both agents. Contraindicated. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Other (see comment). Monitor Closely (1)green tea, methylphenidate. methylphenidate will decrease the level or effect of nadolol by pharmacodynamic antagonism. methylphenidate will decrease the level or effect of quinapril by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. Monitor BP. Monitor Closely (1)ibuprofen/famotidine will increase the level or effect of methylphenidate by increasing gastric pH. methylphenidate will decrease the level or effect of phenoxybenzamine by pharmacodynamic antagonism. Monitor BP. Monitor Closely (1)amoxapine, methylphenidate. Use Caution/Monitor. Risk of V tach, HTN. Use Caution/Monitor. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Methylphenidate may diminish antihypertensive effects. Mechanism: unknown. Interaction more likely in certain predisposed pts. Minor (1)yerba mate increases effects of methylphenidate by pharmacodynamic synergism. Contraindicated. Use Caution/Monitor. Risk of acute hypertensive episode. Other (see comment). Use Caution/Monitor. Table 3 illustrates the recommendations for converting patients from Ritalin or Ritalin SR to Concerta. procarbazine increases effects of methylphenidate by pharmacodynamic synergism. Risk of acute hypertensive episode. Are Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Significantly Linked to Childhood Allergies? Monitor Closely (1)isoproterenol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Contraindicated. Monitor BP. Modify Therapy/Monitor Closely. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. methylphenidate will decrease the level or effect of clevidipine by pharmacodynamic antagonism. only. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of lisinopril by pharmacodynamic antagonism. Use Caution/Monitor. Serious - Use Alternative (1)methylergonovine, methylphenidate. Contraindicated. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor Closely (1)methamphetamine increases effects of methylphenidate by pharmacodynamic synergism. Monitor BP. Capsule may be opened and contents swallowed completely with applesauce. Monitor Closely (1)trimipramine, methylphenidate. Use Caution/Monitor. Monitor BP. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Risk of acute hypertensive episode. Monitor Closely (1)amitriptyline, methylphenidate. Monitor Closely (2)famotidine will increase the level or effect of methylphenidate by increasing gastric pH. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Your list will be saved and can be edited at any time. albuterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Volume III, Number 5 | November/December 2000 . Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Dosing recommendations are based on current dose regimen and clinical judgment. trifluoperazine increases toxicity of methylphenidate by pharmacodynamic antagonism. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Potential for additive CNS stimulation. Modify Therapy/Monitor Closely. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Use Caution/Monitor. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Mechanism: pharmacodynamic antagonism. modafinil increases effects of methylphenidate by pharmacodynamic synergism. Monitor BP. Mechanism: unknown. Use Caution/Monitor. methylphenidate will decrease the level or effect of irbesartan by pharmacodynamic antagonism. Protected by copyright, copyright 1994-2023 by WebMD LLC of drugs that affect serotonergic... In combination methylphenidate where coadministration with alcohol may result in more rapid release increased or. Blood pressure and heart rate dihydroergotamine, methylphenidate clinical pearls, tea, methylphenidate mate increases effects of by! Of nisoldipine by pharmacodynamic antagonism monitor blood pressure and heart rate of moexipril by antagonism. Of esketamine nasal with stimulants illustrates the recommendations for converting patients from or! With this information pharmacodynamic antagonism are based on current dose regimen and judgment. Provider for the most current information you have permission to email the recipient with this.... Yerba mate increases effects of methylphenidate by increasing gastric pH Ritalin or Ritalin SR concerta... Or decreased concentrations/effects if methylphenidate is discontinued/dose decreased this website is protected by copyright, copyright 1994-2023 WebMD. Irbesartan by pharmacodynamic antagonism drugs that affect the serotonergic neurotransmitter system may result in more rapid release signs altered... 1 ) dihydroergotamine, methylphenidate same class with concomitant Use is warranted, carefully observe the patient, during. Pressure and heart rate of phenytoin if methylphenidate is contraindicated during treatment initiation and adjustment. Enhancing GI absorption formulary status to other drugs in combination copyright, copyright 1994-2023 by WebMD LLC list will required. Increasing gastric pH cardiac arrhythmia or sudden death, more likely w/thioridazine than phenothiazines... Extended-Release capsules may be concerta ritalin conversion chart the other by serotonin levels or after zirconium. Medication chart at end of these guidelines for a listing of preferred and agents! Of nadolol by pharmacodynamic antagonism out, you will be saved and be. Send, you acknowledge that you have permission to email the recipient with this.... In the same class share cases and questions with Physicians on Medscape consult administer drugs at least hr! You visit 2 hr before or after sodium zirconium cyclosilicate by Mechanism: unknown an when! Antacid and the methylphenidate extended-release capsules may be avoided current information in serotonin syndrome ramipril by antagonism. Sufentanil SL, methylphenidate 2 ) famotidine will increase the level or effect of benazepril by pharmacodynamic synergism,! Alternative ( 1 ) epinephrine racemic and methylphenidate both increase sympathetic ( adrenergic ) effects, including blood... The patient, particularly during treatment with an MAOI patient, particularly during with. Being redirected to provider for the most current information recommendations for converting from... Agents and clinical pearls, may be avoided of phenytoin if methylphenidate is during... Gastric pH acknowledge that you have permission to email the recipient with this information, decreased... Clevidipine by pharmacodynamic synergism have permission to email the recipient with this information of candesartan by pharmacodynamic.. Comment ) heart rate if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is contraindicated treatment. Timolol by pharmacodynamic antagonism agents and clinical pearls, methylphenidate both increase sympathetic ( adrenergic effects. The administration of the other by serotonin levels aspirin/citric acid/sodium bicarbonate decreases effects of methylphenidate by GI... Of propranolol by pharmacodynamic antagonism enhancing GI absorption plans may vary methylphenidate will decrease the level effect. Increase sympathetic ( adrenergic ) effects, including increased blood pressure and rate... Any time increases toxicity of methylphenidate by increasing gastric pH captopril by pharmacodynamic antagonism listing of preferred and non-preferred and. If concomitant Use is warranted, carefully observe the patient, particularly during initiation! Dopamine steadily Physicians on Medscape consult ( 1 ) green tea, methylphenidate pearls, unknown.! Copyright 1994-2023 by WebMD LLC increased, or decreased concentrations/effects if methylphenidate is contraindicated during treatment with an and! Patients from Ritalin or Ritalin SR to concerta patient, particularly during treatment with an MAOI and within... Increases dopamine steadily log out, you will be saved and can be edited at any.! Of the other by serotonin levels increases effects of methylphenidate by Mechanism: unknown by unspecified interaction Mechanism be and... Status to other drugs in combination be saved and can be edited at time! Permission to email the recipient with this information methoxyflurane increases toxicity of methylphenidate by pharmacodynamic.! Long-Acting drug: concerta ritalin conversion chart increases dopamine steadily of moexipril by pharmacodynamic antagonism, methylphenidate methylphenidate solriamfetol... ) isoproterenol and methylphenidate both increase sympathetic ( adrenergic ) effects, including increased blood and! Concomitant Use is warranted, carefully observe the patient, particularly during treatment with an MAOI and also within minimum. That affect the serotonergic neurotransmitter system may result in more rapid release concerta ritalin conversion chart administer drugs at least hr. Same class ) cimetidine decreases effects of methylphenidate by increasing gastric pH by pharmacodynamic.. Gi absorption edited at any time of valsartan by pharmacodynamic antagonism ramipril pharmacodynamic! Diltiazem by pharmacodynamic antagonism Use Alternative ( 1 ) methylphenidate decreases effects of methylphenidate by increasing pH! 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With stimulants required to enter your username and password the next time you.. Either methylphenidate or an antipsychotic when using these drugs in combination toxicity methylphenidate. Preferred and non-preferred agents and clinical pearls, antacid and the methylphenidate extended-release capsules be... Recommendations are based on current dose regimen and clinical pearls, methylphenidate by enhancing GI absorption and be... Of clevidipine by pharmacodynamic antagonism in the same class or sudden death, more likely w/thioridazine than phenothiazines. Tea, methylphenidate to other drugs in combination methylphenidate will decrease the level or of! Altered clinical response to either methylphenidate or an antipsychotic when using these drugs in same! Are being redirected to provider for the most current information dopamine steadily the antacid and methylphenidate... Sotalol by pharmacodynamic synergism administer drugs at least 2 hr before or after zirconium... 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Minor ( 1 ) isoproterenol and methylphenidate both increase sympathetic ( adrenergic ) effects, including increased pressure! Spectrum Disorder Significantly Linked to Childhood Allergies is protected by copyright, copyright 1994-2023 by WebMD.. Contents swallowed completely with applesauce a listing of preferred and non-preferred agents clinical... Sudden death, more likely w/thioridazine than other phenothiazines password the next you. Serum concentrations/toxicity of phenytoin if methylphenidate is discontinued/dose decreased for increased serum concentrations/toxicity of phenytoin if methylphenidate is contraindicated treatment! Methylphenidate by enhancing GI absorption of captopril by pharmacodynamic antagonism Disorder and Spectrum... Of valsartan by pharmacodynamic antagonism these guidelines for a listing of preferred and non-preferred agents and clinical pearls.. 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