golden, yellow, glow, A familiar that follows Isaac and blocks any shots that hit it, If a projectile is blocked by Dry Baby, he has a 10% chance to activate the Necronomicon effect, dealing 40 damage to the entire room, The chance to activate the effect is not changed by your Luck stat, * item room, treasure room, item room pool, dry baby is best baby, northernlion, fat skeleton, Although extremely unlikely, Isaac can shoot a total of 16 blood beams at a time via multi-shot items. Using the box again will put the picked up items back on the floor again, allowing you to move things between rooms, Can move any of the following: Batteries, Items, Trinkets, Hearts, Keys, Bombs, Coins, Chests and more, Using Moving Box with Car Battery will trigger 2 interactions at the same time: First it will drop all items currently inside the box and secondly will then pick up the current room's contents, When used in a room with 2 items you can choose from (e.g. Works in shops and devil deals as well, allowing you to take them for no cost. The 2 permanent stat increases depend on the item taken: A Snack = +0.2 shot speed, +1 luck. This includes all sources of damage, including environmental damage to enemies, Killing an enemy while berserk will increase the duration of the effect by 1 second, You don't die while in Berserk mode, but taking lethal damage will kill you after the effect wears off, The bone sword from this item is similar to Donkey Jawbone from Antibirth, Tainted Samson starts with a passive version of this item, UNLOCK: Unlock this item by defeating Delirium as Tainted Samson, Recharge time: Enemy damage taken = charge, When used, Isaac turns into a ghost for 1 second and his speed goes up to maximum (2.0). Placing a bomb this way will not affect your devil/angel room chances, Lil Dumpy follows Isaac and produces a Butter Bean fart when a projectile or enemy is about to hit Isaac, pushing the enemy back and preventing the damage, After it farts, it flies away, stops following Isaac and has to be picked up again before it will follow again, He also has a second larger detection radius that can randomly trigger from enemy projectiles, The effect only works if Lil Dumpy is following and near Isaac, You have a chance alongside each tear to shoot a red flame, which deals damage to enemies that come in contact with it, Damage starts at x4 your current tear damage, and scales down each time an enemy touches the fire, The chance to create a fire scales with your Luck stat, at +11 Luck you have a 50% chance to shoot one, The flames from this item can destroy shopkeepers, which is handy since doing this once per floor increases your devil/angel room chances slightly. Seeds Essentially you are rerolling all your items, but each new item you get to choose between 3 random options, The bedroom also contains a random trinket, 2 chests, 2 sacks and Isaac's bed, which can be used to full heal your red heart health, The only way to exit Isaac's bedroom is teleporting out or via the trapdoor, which takes you to the next floor. The familiar uses Isaac's tears, range, shot speed, and tear effects, and deals 0.35x Isaac . All you gotta do is Ctrl+F the real name of the item. Using this card will also open a pathway of red rooms back to the regular floor, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Jacob, "May the darkness swallow all around you", When used, grants +1.5 Damage Up, turns your hearts to Bone hearts and the Spirit of the Night effect (Spectral tears and the ability to fly) for the current floor, Also gives the Curse of Darkness effect that can't be removed for the current floor, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Lazarus, Creates a trapdoor to a guaranteed crawl space, UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Eden, When used, this copies the effect of the card, pill, rune, soul stone or active item you used most recently, UNLOCK: Unlock this card by defeating Mega Satan as Tainted Eden, Turns all pedestal items in the current room into rotating items, which cycle between the old item and a random new item every second, This allows you to effectively reroll items like with The D6, but choose the old item as well if you want, Tainted Isaac has this effect passively for all items, If you use more than one in the same room, each pedestal item will cycle through +1 random item, Items are chosen from the item pool related to the current item, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Isaac, When used, all enemies in the current room drop half a red heart that will disappear after 2 seconds if not picked up, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Magdalene, When used, this Soul Stone creates Red rooms for every possible exit in the current room, Red outlines of doors appear where this Soul Stone will create exits for, See the Red Key item description for more information about these Red rooms behave, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Cain, Activates the Dark Arts item effect, which turns Isaac into a ghost for a few seconds. Completion Marks Each use also gives +0.5 Black Hearts, however this is stays between rooms unlike the other effects, Allows Isaac to deal 40 contact damage to enemies for the current room. Characters With poison effects, the damage over time poison will last for much longer. Additional copy of Monstro's Lung adds 3-5 more rings. blue, glow, arrow, cross, * astrology, astronomy, item room, treasure room, item room pool, cyan, black, blue, glow, n, tail, Leaves a trail of tears on the floor behind Isaac which damages enemies that walk over it for 2 damage per tick, REPENTANCE - Aquarius now synergizes with tear effects, * astrology, astronomy, item room, treasure room, item room pool, black, blue, cyan, blue, glow, and IBS also have special effects: Stone Dips deal 3.5 more damage and can take 6 hits before they die. UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted ??? Stat Down pills do nothing, and items like Experimental Treatment increase stats but don't reduce any, This effect works on items that apply negative stat modifiers, such as Soy Milk, This effect works for anything that gives temporary buffs, like Devil/Strength cards, or kill bonuses like Bloody Lust, If you somehow lose Rock Bottom, your stats will go back to normal, UNLOCK: Unlock this item by defeating the Boss Rush as Jacob & Esau, Bombs now explode with a random effect (e.g. * boss room pool, boss room item, brown, leather, bag, sack, golden chest pool, gold chest pool, Gives 3-6 blue attack flies when picked up, Item Pool: Boss Room, Challenge Room, Gold/Stone Chest, Mom's Chest, * dungeon room, blood challenge room, arena pool, boss room pool, boss room item, panties, blue, white, triangle, Isaac's tears become large, brown and will penetrate all objects and enemies (piercing + spectral), Despite the increase in tear size, Dead Onion does NOT increase your damage stat. To help with range, the orbit is now also offset based on the current direction Isaac is shooting, * item room, treasure room, item room pool, grey, gray, asteroid, silver, ball, Creates a friendly blue spider when you kill an enemy, Spiders are spawned at the location where the enemy died, * item room, treasure room, item room pool, pink, smile, E. Coli turns normal enemies into poop if they touch you, Enemies can turn into poop even if they do not do contact damage, allowing you to apply the effect without taking damage, Can be combined with Midas Touch to turn enemies into Golden Poop, This does not work on mini-bosses and bosses. Half hearts heal a whole heart and full hearts heal 2 red hearts, UNLOCK: Unlock this item by beating Boss Rush with Maggy, * item room, treasure room, item room pool, the lost item pool, pink, purple, candy, Each time you enter a new room, damage is negated for the first time you get hit, Can be used to go in and out of a Curse Room without taking damage. The medical name for a blood clot is a 'venous thromboembolism'. Acts like a Shooter, except they shoot out a Brimstone shot. Blood Clot / Chemical Peel / The Peeper: 50% chance to apply the flat damage up/damage increase with each shot. Counts as 1 of 3 angel items needed towards the Seraphim transformation. Red chests), Can be used in a shop to duplicate pickups which have not yet been purchased, and take the duplicate pickup for free, UNLOCK: Unlock this item by defeating Greedier Mode with Isaac, When used, Void will consume any pedestal items in the current room, If an active item is consumed, its effect will be added to Void's effect when used, allowing you to consume multiple items and combine their effects, If a passive item is consumed, you gain a small stat upgrade to a random stat, Possible stat changes include: +1.0 flat damage, +0.5 tears, +0.2 speed, +0.2 shot speed, +0.5 range, +1.0 luck, Void does not work on devil deal or shop items unless they have been bought first, Using Void to absorb items in Boss Rush or Challenge Rooms counts as taking the items and will cause the encounter to start, Using Void on one time use items such as Mama Mega or Diplopia will cause their effect to instantly trigger and will not give you further uses through activating Void again, UNLOCK: Unlock this item by beating Delirium in The Void floor with Apollyon, Upon use, this item freezes all enemies in the room until you press the fire button again or 30 seconds passes (whichever happens first), Unlike other active items, bosses are not immune to this effect, Touching a frozen enemy will still hurt you, This item doesn not affect troll bombs - they will still explode, Upon use, the Smelter will destroy your currently held trinket and give you the effect permanently, allowing you to stack up lots of different trinket effects, Holding the Smelter increases the chance for a trinket to drop. 5.100.531 Counts as 1 of 3 familiar items needed towards the Conjoined transformation. Poison deals 5 damage initially and then 3.5, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Isaac, REPENTANCE - GB Bug is now a thrown projectile, activated by double tapping an attack button. 2 keys = 50% chance. Isaac appears demonic with large curved horns and an angry expression. Binding of Isaac: Rebirth Wiki is a FANDOM Games Community. Rarer clots have unique effects on tearsBone Clot tears have Compound Fracture, Gold Clots have Midas Touch, Eternal Hearts have Sacred Heart, and Black Hearts have Dark Matter. Based on the Steam Workshop mod created by Maddogs, UNLOCK: Unlock this item by picking up Rubber Cement 5 times, Spawns 3 red hearts on the ground when picked up, Added as part of the Afterbirth+ Booster Pack #5, UNLOCK: Unlock this item by defeating Mom's Heart on hard mode as The Forgotten, This item gives you an orbital, which will reflect projectiles back at enemies, Unlike some other orbitals, Slipped Rib doesn't deal contact damage to enemies, UNLOCK: Unlock this item by defeating the Isaac boss as The Forgotten, A familiar which follows Isaac and spawns a white poop when you take damage, The white poop gives an aura that cuts your tear delay in half (Tears up) and has a chance to block damage, The aura disappears if the poop is destroyed. Tainted Eve starts with 2 red . Rooms Kills poop bosses when used - Dingle, Dangle and Brownie, * item room, treasure room, item room pool, silver spoon handle, grey, gray, white, toilet. UNLOCK: Unlock this card by opening Mom's Box on the Home floor. Can cause white poops through other item effects such as A Card Against Humanity or Re-Lax pills. "I am very excited to get out on the road," says the 27-year . Magic 8 Ball Squeezy Jesus Juice), Familiars and Orbitals: Brother Bobby Halo Of Flies Distant Admiration Sister Maggy Guardian Angel Demon Baby Dead Bird Forever Alone Sack Of Pennies Bomb Bag +0.5 tear falling speed. Isaac takes a full heart if hurt by Blood Puppy and it drops a full red heart for every 10 enemies it kills. Yeah I saw one of those rooms on the map too. . An increased damage stat does increase Brimstone's damage. Generally every interaction and synergy that applies to Chemical Peel also . Chemical Peel is a passive item. Once you've beaten Mother once, a door will appear at the starting room in Depths II, which leads to the Mausoleum/Gehenna floors. Blood Clot: All tears are larger, with increased damage (as opposed to every 2nd tear like Blood Clot alone). achievement (collect 50 items in a single run), X-Lax - Spawns a pool of slippery brown creep beneath Isaac, Experimental Pill - Increases one random stat and decreases another random stat. the lost item pool, gold, orange, yellow, cross, pope, hat, A familiar the follows Isaac and fires random tears, Rainbow Baby's tears can choose from any of the other familiars, such as homing, spectral, tar shots etc, * item room, treasure room, item room pool, purple, Upon use, opens all closed doors in the current room, including the ones which require a key to enter and secret room doors, Can be used to open the golden door that appears in the Dark Room or the Chest, Cannot be used to escape the Mom's Foot boss, open angel/devil rooms, or open the door to the Blue Womb floor, UNLOCK: Unlock this item by collecting both Key Pieces #1 & #2 for the first time, * key master pool, key beggar pool, key judgement pool, item room, treasure room, item room pool, Blood Clot DMG + range up . Characters This means if you roll into The Lost, changing back to another character will leave you with only 1/2 of a soul heart, Cannot turn you into a character that isn't unlocked yet, Also includes Lazarus II (Lazarus' revived form) and Dark Judas (effect of Judas' Shadow), It's also possible that this item will pick the same character, making it seem like nothing happened, *, grey, gray, black, remote, zapper, changer, building, A one time use item that when used will explode all objects (i.e. The Binding of Isaac Rebirth and Afterbirth has been updated to version 1.15 and 1.05 today. increased tears stat does not reduce the charge up time of Brimstone. Chocolate Milk: Lasers can't be charged, but reduces Isaac's tear delay by 20%. If you get hit in either of the other 2 states you will not be teleported, The Black Candle item will remove the Cursed Eye's teleportation effect, REPENTANCE - Burst now has 5 shots instead of 4, * secret room pool, item room, treasure room, item room pool, white, circle, pearl, When Isaac's tears hit anything, they leave a green toxic creep on the floor that damages enemies for 1 damage per tick, * item room, treasure room, item room pool, mystery liquid, grey, gray, green, A familar that is attached to Isaac, which will seek out and damage any enemies close by for 3 contact damage, * astrology, astronomy, item room, treasure room, item room pool, blue, glow, A familiar eye that follows Isaac and copies all his tear modifiers/effects, but shoots in random directions, Tears from this familiar deal 75% of Isaac's tear damage, UNLOCK: Unlock this item by beating Boss Rush with Cain, * item room, treasure room, item room pool, eyeball, white, circle, cataract, cains other eye, A familiar fly that can be moved around via use of the arrow keys dealing 2.5 contact damage per tick, similar to the Ludovico Technique's mechanic, UNLOCK: Unlock this item by beating Boss Rush with Blue Baby, * item room, treasure room, item room pool, blue fly, big fly, blue baby's only friend, fat, dead, ?? 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